Team BDB

Advanced Biomarker Detection for Pharmacological Monitoring in the Brain

The objective of the research group is to develop an in vivo continuous monitoring biosensor for direct detection of small molecule biomarkers in brain tissue of rodent models for elucidating pharmacodynamic (PD) effect and pharmacokinetic (PK) parameters of drugs against neuropsychiatric diseases. The team will explore the multifaceted task of continuous monitoring biosensor development, including molecular design and assay development, biocompatible sensor architecture, and sensor integration for in vivo monitoring.

  • Mentors

    Prof. Dr. Bastian Hengerer
    Director CNS Diseases Research at Boehringer Ingelheim (Industry mentor)

The research of this team is kindly sponsored by Boehringer Ingelheim.

Our Team Members

Khulan Sergelen

Group Leader

  • Short Bio
    • 2019-2022: Assistant Professor (tenure-track) and 2018-2019: Postdoctoral researcher at Molecular Biosensing for Medical Diagnostics (MBx) group, Eindhoven University of Technology, Netherlands
      Continuous monitoring biosensors based on particle mobility for inflammatory biomarkers monitoring application
    • 2012-2017: PhD joint degree in Bionanotechnology (IGS-BioNanoTech) at the University of Natural Resources and Life Sciences (BOKU), Vienna and Nanyang Technological University (NTU), Singapore
      Reversible biosensors using aptamer-based surface plasmon-enhanced fluorescence spectroscopy and hydrogel architectures towards therapeutic drug monitoring application
    • 2009-2012: MSc Molecular Medicine, University of Vienna, Austria
      Protein microarray screening of tumor autoantibodies for early colon cancer detection- Austrian Institute of Technology, Vienna
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Simone Hageneder

Postdoctoral Researcher

  • Short Bio
    • 2020-2022: Junior Scientist at Biosensor Technologies, Austrian Institute of Technology (AIT), Tulln, Austria
    • 2016-2021: PhD in Nanobiotechnology at the University of Natural Resources and Life Sciences (BOKU), Vienna, Austria, and the Austrian Institute of Technology (AIT), Tulln, Austria, on interfaces and plasmonic nanostructures for detection of biomarkers
    • 2013 – 2016: Master of Science in Biotechnology at the University of Natural Resources and Life Sciences (BOKU), Vienna, Austria
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Cátia Monteiro da Santa

Postdoctoral Researcher

  • Short Bio
    • 2020: PhD in Experimental Biology and Biomedicine – Neuroscience and Disease from the University of Coimbra, Portugal
    • 2011: Master’s in Biochemistry – Biomolecular Methods from the University of Aveiro, Portugal
    • 2009: Bachelor in Biochemistry from the University of Aveiro, Portugal
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