Neuroscience

Team BDB

Advanced Biomarker Detection for Pharmacological Monitoring in the Brain

The objective of the research group is to develop an in vivo continuous monitoring biosensor for direct detection of small molecule biomarkers in brain tissue of rodent models for elucidating pharmacodynamic (PD) effect and pharmacokinetic (PK) parameters of drugs against neuropsychiatric diseases. The team will explore the multifaceted task of continuous monitoring biosensor development, including molecular design and assay development, biocompatible sensor architecture, and sensor integration for in vivo monitoring.

 Mentors

Prof. Dr. Bastian Hengerer
Director CNS Diseases Research at Boehringer Ingelheim (Industry mentor)

TBD (Academic mentor)

The research of this team is kindly sponsored by Boehringer Ingelheim.

Our Team Members

Dr. Khulan Sergelen

Group Leader

 Short Bio
  • 2019-2022: Assistant Professor (tenure-track), Eindhoven University of Technology, Netherlands
  • 2018-2019: Postdoctoral researcher at Molecular Biosensing for Medical Diagnostics (MBx) group, Eindhoven University of Technology, Netherlands
    • Continuous monitoring biosensors based on particle mobility for inflammatory biomarkers monitoring application
  • 2012-2017: PhD joint degree in Bionanotechnology (IGS-BioNanoTech) at the University of Natural Resources and Life Sciences (BOKU), Vienna and Nanyang Technological University (NTU), Singapore
    • Reversible biosensors using aptamer-based surface plasmon-enhanced fluorescence spectroscopy and hydrogel architectures towards therapeutic drug monitoring application
  • 2009-2012: MSc Molecular Medicine, University of Vienna, Austria
    • Protein microarray screening of tumor autoantibodies for early colon cancer detection- Austrian Institute of Technology, Vienna
 Contact

Dr. Simone Hageneder

Postdoctoral Researcher

 Short Bio
  • 2020-2022: Junior Scientist at Biosensor Technologies, Austrian Institute of Technology (AIT), Tulln, Austria
  • 2016-2021: PhD in Nanobiotechnology at the University of Natural Resources and Life Sciences (BOKU), Vienna, Austria, and the Austrian Institute of Technology (AIT), Tulln, Austria, on interfaces and plasmonic nanostructures for detection of biomarkers
  • 2013 – 2016: Master of Science in Biotechnology at the University of Natural Resources and Life Sciences (BOKU), Vienna, Austria
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Dr. Cátia Monteiro da Santa

Postdoctoral Researcher

 Short Bio
  • 2013 – 2020: PhD in Experimental Biology and Biomedicine – Neuroscience and Disease from the University of Coimbra, Portugal
  • 2009 – 2011: Master of Science in Biochemistry – Biomolecular Methods from the University of Aveiro, Portugal
  • 2006 – 2009: Bachelor in Biochemistry from the University of Aveiro, Portugal
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Dr. Pragnya Satapathy

Postdoctoral Researcher

 Short Bio
  • 2016 – 2022: PhD in Physics, Centre for Nano and Soft Matter Sciences, India. Broad Area: Soft Condensed Matter Physics. Thesis title: “Photo-driven effects in nano-soft composites with liquid crystal/polymer hosts”
  • 2014 – 2016: Master of Science in Physics, Pondicherry University, India. Result: First Rank holder (Gold Medallist). Dissertation: “Study of Surface Enhanced Raman Scattering (SERS) Effect and Reusability of Ag/ZnO/Ag Hybrid Structure Based SERS substrate”
  • 2011 – 2014: Bachelor of Science in Physics (Hons.), Berhampur University, Odisha, India. Result: First class division with distinction
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