Immunology
Team TMI
Translocation of Complex Macromolecules Across the Intestinal Epithelial Barrier
The main objective of the research group TMI is to discover novel transport mechanisms in the human intestinal tract which could be utilized for oral-systemic delivery of diverse therapeutic modalities (e.g., peptides, oligonucleotides, and antibodies). Studies involve screening of ligands, generating intestinal organoids from murine and human subjects, isolating intestinal cells, and creating a co-culture system. The project’s objectives are to develop a ligand specific for a target cell and establish quantitative assessment methods to monitor macromolecular drug delivery across the intestinal epithelial barrier. Our final goal is to create a novel delivery platform, which can be utilized for the development of a new generation of oral immunotherapies for the benefit of patients.
Mentors
- Dr. Kasper Hoebe
Associate Director Janssen R&D (Industry mentor) - Dr. Diana Dudziak Professor for Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Germany (Academic mentor)
Our Team Members
Dr. Kyungbo Kim
Group Leader
Short Bio
- 2018-2021: Post-doc in Insect development and molecular biology with Prof. Subba Reddy Palli, the University of Kentucky Department of Entomology, USA
- 2013-2018: PhD in Pharmaceutical sciences in the Laboratory of Prof. Chang-Guo Zhan, the University of Kentucky College of Pharmacy, USA
- 2012-2013: RA in Cancer biology in the Laboratory of Prof. Wooin Lee, the University of Kentucky College of Pharmacy, USA
- 2009-2011: MS in Biotechnology in the Laboratory of Prof. ‪Dong-Eun Kim, Konkuk University, Korea
Dr. Enrique Gamero
Postdoctoral Researcher
Short Bio
- 2015-2021: PhD on epithelial biology and development in the laboratory of Dr. Aimee Ryan, Department of Human Genetics, McGill University, Montreal, Canada
- 2013-2015: Undergraduate research assistant studying aging in mice in the laboratory of Dr. Guillermo Lopez Lluch, CABD, University Pablo de Olavide, Sevilla, Spain
- 2010-2014: Undergraduate in Biotechnology, University Pablo de Olavide, Sevilla, Spain
Dr. Stephanie MĂĽnchau
Postdoctoral Researcher
Short Bio
- 2017 – 2021: PhD on barrier function and innate immune signaling in the human intestinal mucosa in the lab of Dr. Steeve Boulant and Dr. Megan Stanifer, Center for Integrative Infectious Diseases research, Virology, Heidelberg University Clinic and DKFZ, Germany
- 2014 – 2017: Master of Science Molecular Biosciences, Major Infectious Diseases, Ruprecht-Karls-University Heidelberg, Germany
- 2010 – 2014: Bachelor of Science Biological Sciences, Ruprecht-Karls-University Heidelberg, Germany
Olivia MĂĽllertz
PhD Student
Short Bio
- 2020-2021: Master of Science in Pharmaceutical Sciences, University of Copenhagen, Denmark
- 2020: Research Placement, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
- 2018-2019: Undergraduate Research Assistant, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
Elizaveta Savochkina
Research Assistant
Short Bio
- 2016 – 2022: Research Assistant in the laboratory of Physiology of Nutrition, Pavlov Institute of Physiology RAS, Saint Petersburg, Russia
Research Assistant in the Almazov National Medical Research Centre of Cardiovascular Diseases (in the laboratory of Contagious and Biomolecular nanostructures and in several others), Saint Petersburg, Russia - 2014 – 2016: Master of Biological Sciences. Major in Cell Biology, Histology, Immunology. Saint-Petersburg State University, Russia
- 2010 – 2014: Bachelor of Biological Sciences. Major in Cell and Molecular Biology, Biotechnology. Saint-Petersburg State University, Russia
Viktoriya Chaskovska
Research Assistant
Short Bio
2022: Internship in the BioTex (Biohybrid & Medical Textiles) Department of The Institute of Applied Medical Engineering of RWTH Aachen University, Germany
2020 – 2022: Master’s degree in Biomedical Engineering, Vilnius Tech, Lithuania
2019 – 2021: Master’s degree in Biotechnology and Bioengineering, Kyiv National Taras Shevchenko University, Ukraine
2015 – 2019: Bachelor’s degree in Biotechnology and Bioengineering, Kyiv National Taras Shevchenko University, Ukraine
Team TMI Alumni
At BioMed X we care for the people who work with us. Staying in touch with those who left but mainly contributed to BioMed X’s success is key. That’s why they have their designated place on our website. So let’s keep connected!