Oncology Research

Team MSC

Metabolism and Signaling in Cancer

Due to stressful microenvironments and accumulation of mutations favoring adaption, cancer cells frequently show alterations in metabolic and other signaling circuits compared with normal cells. As a consequence, cancer cells show increased dependence on certain proteins or stress support pathways, which themselves might not be deregulated through mutational in-/activation (non-oncogene dependence).

Team IMT

Immunosuppressive Microenvironment of Tumors

The IMT research group at the BioMed X Innovation Center is exploring the immunosuppressive tumor microenvironment specifically addressing the role of myeloid-derived suppressor cells (MDSC), tumor associated macrophages (TAM), immature dendritic cells (iDC), and their mechanisms leading to immunosuppression.

Team DDC

DNA Damage in Cancer

Often termed as a disease of the genome, cancer is the result of random acquisition of mutations that activate oncogenes and inactivate tumor suppressors. Consequently, cellular processes including cell cycle control, transcription, apoptosis and DNA repair are affected, conferring incremental growth advantages to cells and fomenting tumorigenesis.

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BioMed X is located on Heidelberg’s Life Science Campus. Within walking distance you will find such institutions as Heidelberg University Hospital, the German Cancer Research Center, the National Center for Tumor Diseases, the Center for Molecular Biology, BioQuant, and – not far from the campus – the European Molecular Biology Laboratory.

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