Oncology – How we fight cancer

Oncology

We foster an environment in which early-career scientists can work together in dedicated projects on tough preclinical challenges to lay the groundwork for the next generation of therapies.

Oncology – learn about the spectrum of our research at BioMed X Institute:

Team DDC

Team DDC

DNA Damage in Cancer

Often termed as a disease of the genome, cancer is the result of random acquisition of mutations that activate oncogenes and inactivate tumor suppressors. Consequently, cellular processes including cell cycle control, transcription, apoptosis and DNA repair are affected, conferring incremental growth advantages to cells and fomenting tumorigenesis.

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Team RSC

Team RSC

RNA Splicing in Cancer

Splicing of mRNA is a crucial process in eukaryotic gene expression regulation, and aberrant splicing plays a critical role in the pathogenesis of several molecular subtypes of cancer. Such splicing abnormalities can lead to constitutive activity of oncogenes, reduced expression of tumor suppressors, or drug resistance. Our team is seeking to identify key molecular mechanisms that generate mRNA splicing abnormalities in cancer.

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