Oncology

Oncology

We foster an environment in which early-career scientists can work together in dedicated projects on tough biomedical challenges to lay the groundwork for the next generation of therapies.

Oncology – learn about the spectrum of research at our BioMed X Institute:

Team RSC

Team RSC

RNA Splicing in Cancer

Splicing of mRNA is a crucial process in eukaryotic gene expression regulation, and aberrant splicing plays a critical role in the pathogenesis of several molecular subtypes of cancer. Such splicing abnormalities can lead to constitutive activity of oncogenes, reduced expression of tumor suppressors, or drug resistance. Our team is seeking to identify key molecular mechanisms that generate mRNA splicing abnormalities in cancer.

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Team SDR

Team SDR

Synthetic Lethality in DNA Repair

The group aims to translate new synthetic lethal interactions between DNA repair genes into novel therapeutic targets in oncology.

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Team EDC

Team EDC

Extrachromosomal DNA in Cancer

The objective of the group will be to investigate the formation, maintenance and consequences of extrachromosomal DNA (ecDNA) in cancer using cutting edge single-cell screening and spatial technologies.

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