Scientific Publications – Publishing the results of our research projects in peer-reviewed journals is key

Scientific Publications

To learn more about the success of our ongoing and completed projects explore our researcher’s scientific publications.

 Metabolism and Signaling in Cancer (MSC)
  1. Ignashkova TI, Gendarme M, Peschk K, Eggenweiler HM, Lindemann RK, Reiling JH (2017):
    Cell survival and protein secretion associated with Golgi integrity in response to Golgi stress-inducing agents
    Traffic 18(8)
  2. RamĂ­rez-Peinado S, Ignashkova TI, van Raam BJ, Baumann J, Sennott EL, Gendarme M, Lindemann RK, Starnbach MN, Reiling JH (2017):
    TRAPPC13 modulates autophagy and the response to Golgi stress
    Journal of Cell Science 130
  3. van Raam BJ, Lacina T, Lindemann RK, Reiling JH (2017):
    Secretory stressors induce intracellular death receptor accumulation to control apoptosis
    Cell Death and Disease 8(10)
  4. Gendarme M, Baumann J, Ignashkova TI, Lindemann RK, Reiling JH (2017):
    Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1
    Molecular Biology of the Cell 28(26)
  5. Baumann J, Ignashkova TI, Chirasani SR, RamĂ­rez-Peinado S, Alborzinia H, Gendarme M, Kuhnigk K, Kramer V, Lindemann RK, Reiling JH (2017):
    Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing
    Molecular Biology of the Cell 29(1)
  6. Alborzinia H, Ignashkova TI, Dejure FR, Gendarme M, Theobald J, Wölfl S, Lindemann RK, Reiling JH (2018):
    Golgi stress mediates redox imbalance and ferroptosis in human cells
    Communications Biology 1

Read more

 Selective Kinase Inhibitors (SKI)
  1. Volkamer A, Eid S, Turk S, Jaeger S, Rippmann F, Fulle S (2014):
    The pocketome of human kinases: Prioritizing the ATP binding sites of (yet) untapped protein kinases for drug discovery
    Journal of Chemical Information and Modeling 55(3)
  2. Volkamer A, Eid S, Turk S, Rippmann F, Fulle S (2016):
    Identification and visualization of kinase-specific subpockets
    Journal of Chemical Information and Modeling 56(2)
  3. Merget B, Turk S, Eid S, Rippmann F, Fulle S (2017):
    Profiling prediction of kinase inhibitors: Toward the virtual assay
    Journal of Medicinal Chemistry 60(1)
  4. Eid S, Turk S, Volkamer A, Rippmann F, Fulle S (2017):
    KinMap: A web-based tool for interactive navigation through human kinome data
    BMC Bioinformatics 18
  5. Turk S, Merget B, Rippmann F, Fulle S (2017):
    Coupling matched molecular pairs with machine learning for virtual compound optimization
    Journal of Chemical Information and Modeling 57(12)
  6. Sorgenfrei FA, Fulle S, Merget B (2018):
    Kinome-wide profiling prediction of small molecules
    ChemMedChem 13(6)
  7. Jaeger S, Fulle S, Turk S (2018):
    Mol2vec: Unsupervised machine learning approach with chemical intuition
    Journal of Chemical Information and Modeling 58(1)
  8. Turk S, Merget B, Eid S, Fulle S (2018):
    From cancer to pain target by automated selectivity inversion of a clinical candidate
    Journal of Medicinal Chemistry 61(11)
  9. Schwarz D, Merget B, Deane C, Fulle S (2019):
    Modelling conformational flexibility of kinases in inactive states
    Proteins 87(11)

Read more

 Immunosuppressive Microenvironment of Tumors (IMT)
  1. Schröder M, Loos S, Naumann SK, Bachran C, Krötschel M, Umansky V, Helming L, Swee LK (2017):
    Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening
    OncoImmunology 6(1)
  2. Bachran C, Schröder M, Conrad L, Cragnolini JJ, Tafesse FG, Helming L, Ploegh HL, Swee LK (2017):
    The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent
    Scientific Reports 7(1)
  3. Schröder M, Krötschel M, Conrad L, Naumann SK, Bachran C, Rolfe A, Umansky V, Helming L, Swee LK (2018):
    Genetic screen in myeloid cells identifies TNF-α autocrine secretion as a factor increasing MDSC suppressive activity via Nos2 up-regulation
    Scientific Reports 8
  4. Wöll S, Schiller S, Bachran C, Swee LK, Scherließ R (2018):
    Pentaglycine lipid derivates – rp-HPLC analytics for bioorthogonal anchor molecules in targeted, multiple-composite liposomal drug delivery systems
    International Journal of Pharmaceutics 547(1-2)
  5. Wöll S, Bachran C, Schiller S, Schröder M, Conrad L, Swee LK, Scherließ R (2018):
    Sortaggable liposomes: Evaluation of reaction conditions for single-domain antibody conjugation by Sortase-A and targeting of CD11b+ myeloid cells
    European Journal of Pharmaceutics and Biopharmaceutics 133
  6. Wöll S, Bachran C, Schiller S, Schröder M, Conrad L, Scherließ R, Swee LK (2019):
    Sortagging of liposomes with a murine CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells
    European Journal of Pharmaceutics and Biopharmaceutics 134

Read more

 Epigenetics and COPD (EAC)
  1. Jurkowska RZ, Jurkowski TP (2019):
    Establishment, erasure and synthetic reprogramming of DNA methylation in mammalian cells
    In: The DNA, RNA, and histone methylomes (Springer)
  2. Llamazares Prada M, Espinet E, Mijosek V, Schwartz U, Waszak SM, Lutsik P, Tamas R, Richter M, Behrendt A, Pohl S, Benz N, Muley T, Warth A, Heussel CP, Winter H, Herth F, Mertens T, Karmouty-Quintana H, Koch I, Benes V, Korbel JO, Trumpp A, Wyatt D, Stahl H, Plass C, Jurkowska RZ (2020):
    Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung
    JCI Insight 6 (6)

Read more

 Nanomaterial-Based Biosensors (NBB)
  1. Gutiérrez-Sanz Ó, Andoy NM, Filipiak MS, Haustein N, Tarasov A (2017):
    Direct, label-free, and rapid transistor-based immunodetection in whole serum
    ACS Sensors 2(9)
  2. Filipiak MS, Rother S, Andoy NM, Knudsen AC, Grimm S, Bachran C, Swee LK, Zaumseil J, Tarasov A (2018):
    Highly sensitive, selective and label-free protein detection in physiological solutions using carbon nanotube transistors with nanobody receptors
    Sensors and Actuators B: Chemical 255(2)
  3. Andoy NM, Filipiak MS, Vetter D, Gutiérrez-Sanz Ó, Tarasov A (2018):
    Graphene-based electronic immunosensor with femtomolar detection limit in whole serum
    Advanced Materials Technologies 3(12)
  4. Haustein N, Gutiérrez-Sanz Ó, Tarasov A (2019):
    Analytical model to describe the effect of poly-ethylene glycol on ionic screening of analyte charges in transistor-based immunosensing
    ACS Sensors 4(4)
  5. Gutiérrez-Sanz Ó, Haustein N, Schroeter M, Oelschlaegel T, Filipiak MS, Tarasov A (2019):
    Transistor-based immunosensing in human serum samples without on-site calibration
    Sensors and Actuators B: Chemical 295
  6. Filipiak MS, Vetter D, Thodkar K, Gutiérrez-Sanz Ó, Jönsson-Niedziółka M, Tarasov A (2020):
    Electron transfer from FAD-dependent glucose dehydrogenase to single-sheet graphene electrodes
    Electrochimica Acta 330
  7. García-Chamé MA, Gutiérrez-Sanz Ó, Ercan-Herbst E, Haustein N, Filipiak MS, Ehrnhöfer DE, Tarasov A (2020):
    A transistor-based label-free immunosensor for rapid detection of tau protein
    Biosensors and Bioelectronics 159
  8. Thodkar K, Cazade PA, Bergmann F, Lopez-Calle E, Thompson D, Heindl D (2021):
    Self-Assembled Pyrene Stacks and Peptide Monolayers Tune the Electronic Properties of Functionalized Electrolyte-Gated Graphene Field-Effect Transistors
    ACS Applied Materials & Interfaces 13

Read more

 Tau-Mediated Neurodegeneration in Alzheimer’s Disease (TNA)
  1. Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, Matthes F, Krauss S, Reinhardt P, Fulle S, Ehrnhoefer DE (2017):
    A validated antibody panel for the characterization of tau post-translational modifications
    Molecular Neurodegeneration 12(1)
  2. Schöndorf DC, Elschami M, Schieck M, Ercan-Herbst E, Weber C, Riesinger Y, Kalman S, Steinemann D, Ehrnhoefer DE (2018):
    Generation of an induced pluripotent stem cell cohort suitable to investigate sporadic Alzheimer’s Disease
    Stem Cell Research 34
  3. Behrendt A, Bichmann M, Ercan-Herbst E, Haberkant P, Schöndorf DC, Wolf M, Fahim SA, Murolo E, Ehrnhoefer DE (2019):
    Asparagine endopeptidase cleaves tau at N167 after uptake into microglia
    Neurobiology of Disease 130
  4. Ercan-Herbst E, Ehrig J, Schöndorf DC, Behrendt A, Klaus B, Gomez Ramos B, Prat Oriol N, Weber C, Ehrnhoefer DE (2019):
    A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain
    Acta Neuropathologica Communications 7(1)
  5. García-Chamé MA, Gutiérrez-Sanz Ó, Ercan-Herbst E, Haustein N, Filipiak MS, Ehrnhöfer DE, Tarasov A (2020):
    A transistor-based label-free immunosensor for rapid detection of tau protein
    Biosensors and Bioelectronics
  6. Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie LePrieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W Meinhardt, Ebru Ercan-Herbst, Dagmar Ehrnhoefer, Andreas Striebinger, Karen Bodie, Corinna Klein, Laura Gasparini, Kerstin Schlegel (2021):
    Tau in the brain interstitial fluid is fragmented and seeding-competent
    BioRXiv
  7. Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini, Dagmar E. Ehrnhoefer (2021):
    SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
    Molecular Neurodegeneration

Read more

 DNA Damage in Cancer (DDC)
  1. Serçin Ö, Reither S, Roidos P, Ballin N, Palikyras S, Baginska A, Rein K, Llamazares M, Halavatyi A, Winter H, Muley T, Jurkowska RZ, Abdollahi A, Zenke FT, Neumann B, Mardin BR (2019):
    A solid-phase transfection platform for arrayed CRISPR screens
    Molecular Systems Biology 15 (12)
  2. Drainas AP, Lambuta RA, Ivanova I, Serçin Ö, Sarropoulos I, Smith ML, Efthymiopoulos T, Raeder B, Stütz AM, Waszak SM, Mardin BR, Korbel JO (2020):
    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
    Cell Reports 31(1)
  3. Roidos P, Sungalee S, Benfatto S, Serçin Ö, Stütz AM, Abdollahi A, Mauer J, Zenke FT, Korbel JO, Mardin BR (2020):
    A scalable CRISPR/CAS9-based fluorescent reporter assay to study DNA double-strand break repair choice
    Nature Communications 11, 4077 (2020)
  4. Dejure F, Butzer J, Lindemann RK, Mardin BR (2020):
    Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14
    Oncotarget. 2020; 11: 4490-4503
  5. Benfatto S, Serçin Ö, Dejure FR, Abdollahi A, Zenke FT, Mardin BR (2021):
    Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality
    Molecular Cancer. 2021; 20:111

Read more

 Brain Microcircuits in Psychiatric Diseases (BMP)
  1. Magdalena Tertil, Urszula Skupio, Justyna Barut, Valentyna Dubovyk, Agnieszka Wawrzczak-Bargiela, Zbigniew Soltys, Slawomir Golda, Lucja Kudla, Lucja Wiktorowska, Klaudia Szklarczyk, Michal Korostynski, Ryszard Przewlocki & Michal Slezak (2018):
    Glucocorticoid receptor signaling in astrocytes is required for aversive memory formation
    Translational Psychiatry 8
  2. Agnieszka Plociennikowska, Jamie Frankish, Thais Moraes, Dolores Del Prete, Franziska Kahnt, Claudio Acuna, Michal Slezak, Marco Binder, Ralf Bartenschlager (2021):
    TLR3 activation by Zika virus stimulates inflammatory cytokine production which dampens the antiviral response induced by RIG-I-like receptors
    Journal of Virology 95(10)
  3. Verena Nold, Michelle Portenhauser, Dolores Del Prete, Andrea Blasius, Isabella Harris, Eliza Koros, Tatiana Peleh, Bastian Hengerer, Iris-Tatjana Kolassa, Michal Slezak & Kelly Ann Allers (2022):
    Impact of Fkbp5 Ă— early life adversity Ă— sex in humanised mice on multidimensional stress responses and circadian rhythmicity
    Molecular Psychiatry

Read more

Image of

Close