Team DDC

DNA Damage in Cancer

Often termed as a disease of the genome, cancer is the result of random acquisition of mutations that activate oncogenes and inactivate tumor suppressors. Consequently, cellular processes including cell cycle control, transcription, apoptosis and DNA repair are affected, conferring incremental growth advantages to cells and fomenting tumorigenesis.

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Team RSC

RNA Splicing in Cancer

Our team is seeking to identify key molecular mechanisms that generate mRNA splicing abnormalities in cancer. Splicing of mRNA is a crucial process in eukaryotic gene expression regulation. In addition to canonical splicing, which leads to the inclusion of constitutive exons into the mature mRNA, the transcriptome is subject to alternative splicing. More than 90% of eukaryotic mRNAs undergo alternative splicing, giving rise to multiple protein-coding isoforms from a single precursor mRNA. Alternative splicing is therefore a major determinant for proteome diversity and organism complexity.

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Team PMI

Pathogen-Mediated Modulation of Innate Immunity

The team is interested in identifying key molecular and cellular mechanisms at the pathogen-host interface which could be exploited as potential targets for the treatment of multiple chronic inflammatory diseases.

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Team IAA

Rapid Identification of Auto-Antigens in Autoimmune Diseases

The team is seeking new platform technologies or concepts which lead to identification of antigens recognized by T cells involved in autoimmune responses.

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Team IEB

Intestinal Epithelial Barrier in Autoimmune Diseases

The main objective of the IEB group is to identify key molecular mechanisms at intestinal epithelial-immune cells interface, in order to identify and develop new therapeutic targets for intestinal barrier loss in autoimmune diseases that will improve patient outcomes.

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Team BMP

Brain Microcircuits in Psychiatric Diseases

Successful treatment of psychiatric diseases remains a major challenge. We explore the contribution of non-neuronal cells to the dysfunction of brain microcircuits underlying mental disorders to provide new, personalized therapies.

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Team EPD

Early Intervention in Psychiatric Diseases

Schizophrenia as being a neurodevelopmental disorder, shows aberrations not only in structure, wiring and chemistry of multiple neuronal systems but also in myelination. The team is interested in deciphering the causes of this so far untapped pathology occurring due to myelination deficits.

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Team EAC

Epigenetics and COPD

The EAC research team is exploring the role of epigenetic regulation in development and progression of the chronic obstructive pulmonary disease (COPD).

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