Team DDC

DNA Damage in Cancer

Often termed as a disease of the genome, cancer is the result of random acquisition of mutations that activate oncogenes and inactivate tumor suppressors. Consequently, cellular processes including cell cycle control, transcription, apoptosis and DNA repair are affected, conferring incremental growth advantages to cells and fomenting tumorigenesis.

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Team RSC

RNA Splicing in Cancer

Our team is seeking to identify key molecular mechanisms that generate mRNA splicing abnormalities in cancer. Splicing of mRNA is a crucial process in eukaryotic gene expression regulation. In addition to canonical splicing, which leads to the inclusion of constitutive exons into the mature mRNA, the transcriptome is subject to alternative splicing. More than 90% of eukaryotic mRNAs undergo alternative splicing, giving rise to multiple protein-coding isoforms from a single precursor mRNA. Alternative splicing is therefore a major determinant for proteome diversity and organism complexity.

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Team PMI

Pathogen-Mediated Modulation of Innate Immunity

The team is interested in identifying key molecular and cellular mechanisms at the pathogen-host interface which could be exploited as potential targets for the treatment of multiple chronic inflammatory diseases.

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Team IAA

Rapid Identification of Auto-Antigens in Autoimmune Diseases

The team is seeking new platform technologies or concepts which lead to identification of antigens recognized by T cells involved in autoimmune responses.

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Team TNA

Tau-Mediated Neurodegeneration in Alzheimer's Disease

Alzheimer's disease is the most common form of dementia worldwide, affecting millions of patients with no therapeutic options available to date. While amyloid plaques have long been recognized as hallmarks of the disease, recent evidence suggests that abnormal post-translational modifications of the Tau protein are strongly involved in disease manifestation and progression.

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Team BMP

Brain Microcircuits in Psychiatric Diseases

Successful treatment of psychiatric diseases remains a major challenge. We explore the contribution of non-neuronal cells to the dysfunction of brain microcircuits underlying mental disorders to provide new, personalized therapies.

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Team EAC

Epigenetics and COPD

The EAC research team is exploring the role of epigenetic regulation in development and progression of the chronic obstructive pulmonary disease (COPD).

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Team NBB

Nanomaterial-Based Biosensors

The NBB team at BioMed X combines state-of-the-art nanomaterials research with biomedical know-how in order to develop a novel electronic sensor platform for the next generation of point-of-care diagnostic devices.

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