Team EDC


Team EDC

Extrachromosomal DNA in Cancer

The objective of the group will be to investigate the formation, maintenance and consequences of extrachromosomal DNA (ecDNA) in cancer using cutting edge single-cell screening and spatial technologies. ecDNA leads to high amplification of oncogenes or genes involved in drug resistance under selective pressures and has a prominent role in cancer heterogeneity. The overarching goal will be to identify druggable targets that reduce ecDNA abundance in cancer – and hence ablating a potent tool of genetic heterogeneity and a powerhorse of drug resistance in cancer.

  • Dr. Ralph Lindemann
    Global Head, Translational & Biomarker Research, TIP Oncology & Immunooncology, Merck, Darmstadt, Germany (Industry mentor)
  • TBD
    (Academic mentor)
The research of this team is kindly sponsored by Merck.

Dr. Alexandros Drainas

Group Leader

 Short Bio
  • 2018-2022: Postdoc in investigating drug resistance and cancer heterogeneity in Small Cell Lung Cancer in the laboratory of Prof. Julien Sage; TRDRP fellow, Division of Pediatrics and Genetics, Stanford Medical University, Stanford, CA, USA
  • 2017-2018: PhD Graduate in Dr. Jan Korbel’s laboratory, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
  • 2012-2016: PhD in Molecular Biology. Supervisor: Dr. Jan Korbel, EMBL, Heidelberg, Germany

Dr. Kun-Yi Lai

Postdoctoral Researcher

 Short Bio
  • 2016-2021: PhD in virology supervised by Prof. Dr. Mario Schelhaas at the Institute of Cellular Virology, University of Münster, Germany
  • 2012-2014: Master of Science in microbiology at the National Taiwan University, Taiwan
  • 2008-2012: Bachelor of Science in biomedical sciences at the Chang Gung University, Taiwan

Dr. Büşra Yağabasan

Postdoctoral Researcher

 Short Bio
  • 2020-2022: Postdoctoral researcher at the Joslin Diabetes Center, Harvard Medical School, Boston, United States
  • 2013-2019: PhD in Molecular and Translation Biomedicine, ETH Zurich, Zurich, Switzerland
  • 2011-2013: Master of Science in Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
  • 2007-2011: Bachelor of Science in Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
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