Team SDR

Synthetic Lethality in DNA Repair

The group aims to translate new synthetic lethal interactions between DNA repair genes into novel therapeutic targets in oncology. By performing targeted pooled screens in cells deficient in DNA repair genes, team SDR will strive to identify and characterize new drug targets in DNA repair and DNA replication as a potent tool to increase the efficiency of clinically used DNA damaging agents.

  • Mentors
    • Dr. Frank Zenke
      Head Cellular Pharmacology, Translational Innovation Platform Oncology at Merck (Industry mentor)
    • Dr. Amir Abdollahi
      Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg (Academic mentor)
The research of this team is kindly sponsored by Merck.

Our Team Members

Dr. Özdemirhan Serçin

Group Leader

  • Short Bio
    • 2016–2021: Postdoctoral Researcher, Team DDC, BioMed X Institute, Heidelberg, Germany
    • 2012–2015: Postdoctoral research fellow in the laboratory of Prof. Dr. Cedric Blanpain, IRIBHM, Université Libre de Bruxelles, Belgium
    • 2006–2011: PhD Student and research assistant in the laboratory of Prof. Dr. Aziz Sancar, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA
  • Contact

Izlem Su Akan

Research Assistant

  • Short Bio
    • 2020–2021: Research Assistant, Team DDC, BioMed X Institute, Heidelberg, Germany
    • 2018 – 2020: Internships at ZMBH and DKFZ, Heidelberg, Germany
    • 2017 – 2020: Master of Science in Molecular and Cellular Biology, University of Heidelberg, Germany
    • 2013 – 2017: Bachelor of Science in Molecular Biology and Genetics, University of Istanbul, Turkey
  • Contact
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