Immunology

Team TMI

Translocation of Complex Macromolecules Across the Intestinal Epithelial Barrier

The main objective of the research group TMI is to discover novel transport mechanisms in the human intestinal tract which could be utilized for oral-systemic delivery of diverse therapeutic modalities (e.g., peptides, oligonucleotides, and antibodies). Studies involve screening of ligands, generating intestinal organoids from murine and human subjects, isolating intestinal cells, and creating a co-culture system. The project’s objectives are to develop a ligand specific for a target cell and establish quantitative assessment methods to monitor macromolecular drug delivery across the intestinal epithelial barrier. Our final goal is to create a novel delivery platform, which can be utilized for the development of a new generation of oral immunotherapies for the benefit of patients.

  • Mentors
    • Dr. Steve Baker
      SDir Novel Platforms Immunology Discovery, Janssen Immunosciences, Spring House, USA (Industry mentor)
    • Dr. Diana Dudziak Professor for Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Germany (Academic mentor)
The research of this team is kindly sponsored by Janssen.

Our Team Members

Dr. Kyungbo Kim

Group Leader

  • Short Bio
    • 2018-2021: Post-doc in Insect development and molecular biology with Prof. Subba Reddy Palli, the University of Kentucky Department of Entomology, USA
    • 2013-2018: PhD in Pharmaceutical sciences in the Laboratory of Prof. Chang-Guo Zhan, the University of Kentucky College of Pharmacy, USA
    • 2012-2013: RA in Cancer biology in the Laboratory of Prof. Wooin Lee, the University of Kentucky College of Pharmacy, USA
    • 2009-2011: MS in Biotechnology in the Laboratory of Prof. ‪Dong-Eun Kim, Konkuk University, Korea
  • Contact

Enrique Gamero

Postdoctoral Researcher

  • Short Bio
    • 2015-2021: PhD on epithelial biology and development in the laboratory of Dr. Aimee Ryan, Department of Human Genetics, McGill University, Montreal, Canada.
    • 2013-2015: Undergraduate research assistant studying aging in mice in the laboratory of Dr. Guillermo Lopez Lluch, CABD, University Pablo de Olavide, Sevilla, Spain.
    • 2010-2014: Undergraduate in Biotechnology, University Pablo de Olavide, Sevilla, Spain.
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Dr. Stephanie Münchau

Postdoctoral Researcher

  • Short Bio
    • 2017 – 2021: PhD on barrier function and innate immune signaling in the human intestinal mucosa in the lab of Dr. Steeve Boulant and Dr. Megan Stanifer, Center for Integrative Infectious Diseases research, Virology, Heidelberg University Clinic and DKFZ, Germany
    • 2014 – 2017: Master of Science Molecular Biosciences, Major Infectious Diseases, Ruprecht-Karls-University Heidelberg, Germany
    • 2010 – 2014: Bachelor of Science Biological Sciences, Ruprecht-Karls-University Heidelberg, Germany
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Olivia Müllertz

Research Assistant

  • Short Bio
    • 2020-2021: Master of Science in Pharmaceutical Sciences, University of Copenhagen, Denmark
    • 2020: Research Placement, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
    • 2018-2019: Undergraduate Research Assistant, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
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