Team PTA

Protective Tissue Factors in Autoimmune Diseases

The main objective of the group is to understand the molecular mechanisms that promote pro-resolution responses in immune and stromal cells to restore homeostasis. In particular, the team will use the human synovium as a model system to characterize the pro-resolving phenotypes of macrophages in rheumatoid arthritis. The core of the project will be the development of a first in kind synovium-in-a-dish assay for systematic monitoring of macrophage functions. Our final goal is to identify new therapeutic targets, which promote pro-resolution in inflammation and autoimmune diseases, and thereby proposing novel concepts to improve patient outcomes.

  • Mentors
    • Dr. Jackie Perrigoue
      Head of Tissue Mechanisms, Janssen Immunosciences, Spring House, USA (Industry mentor)
    • Dr. Scott Berger
      Head of Innate Immunity, Janssen Immunosciences, Spring House, USA (Industry mentor)
The research of this team is kindly sponsored by Janssen.

Our Team Members

Dr. Mojca Frank Bertoncelj

Group Leader

  • Short Bio
    • 2020-2021: Junior Group Leader, Team Integrative biology of immune-mediated inflammatory diseases, University Hospital Zurich & University of Zurich, Zurich, Switzerland
    • 2012-2020: Postdoc in noncoding RNA biology, epigenetics, and functional genomics in autoimmune diseases with Prof. Dr. Steffen Gay & Prof. Dr. Oliver Distler, University Hospital Zurich & University of Zurich, Zurich, Switzerland
    • 2011-2012: Articulum Research Fellow with Prof. Dr. Steffen Gay, University Hospital Zurich & University of Zurich, Zurich, Switzerland
    • 2005-2010: PhD in Biomedicine, Faculty of Medicine & Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    • 1997-2005: Doctor of Medicine, Faculty of Medicine, University of Ljubljana, Slovenia
  • Contact

Dr. Swathi Lingam

Postdoctoral researcher

  • Short Bio
    • 2019-2021: Research Fellow in studying retinal ageing and developing novel cell therapy systems to treat age related retinal degeneration at the National University of Singapore and the Agency for Science, Technology and Research (A*STAR), Singapore.
    • 2017- 2019: Postdoctoral scientist studying the function of the ABC transporter ABCC5 in diabetes at the University of Oxford, United Kindom.
    • 2014- 2017: PhD in biochemistry at the University of Manchester, United Kindom.
  • Contact

Team PTA Alumni

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