Immunology
Team PTA
Protective Tissue Factors in Autoimmune Diseases
The main objective of the group is to understand the molecular mechanisms that promote pro-resolution responses in immune and stromal cells to restore homeostasis. In particular, the team will use the human synovium as a model system to characterize the pro-resolving phenotypes of macrophages in rheumatoid arthritis. The core of the project will be the development of a first in kind synovium-in-a-dish assay for systematic monitoring of macrophage functions. Our final goal is to identify new therapeutic targets, which promote pro-resolution in inflammation and autoimmune diseases, and thereby proposing novel concepts to improve patient outcomes.
Mentors
- Dr. Jackie Perrigoue
Head of Tissue Mechanisms, Janssen Immunosciences, Spring House, USA (Industry mentor) - Dr. Agnès Gardet
Principal Scientist at The Janssen Pharmaceutical Companies of Johnson & Johnson San Diego County, USA (Industry mentor) - Prof. Dr. Greorg Schett
Vice President Research and Chair Internal Medicine at Medicine Faculty at Friedrich-Alexander University (FAU), Erlangen-Nürnberg, Germany, and Director clinical medicine 3 – Rheumatologie und Immunologie, University Hospital Erlangen, Germany (Academic mentor)
Team Location BioMed X Institute Heidelberg
Our Team Members
PD Dr. Mojca Frank Bertoncelj
Group Leader
Short Bio
- 2022: Privatdozentin (PD), University of Zurich, Zurich, Switzerland
- 2020-2021: Junior Group Leader, Team Integrative biology of immune-mediated inflammatory diseases, University Hospital Zurich & University of Zurich, Zurich, Switzerland
- 2012-2020: Postdoc in noncoding RNA biology, epigenetics, and functional genomics in autoimmune diseases with Prof. Dr. Steffen Gay & Prof. Dr. Oliver Distler, University Hospital Zurich & University of Zurich, Zurich, Switzerland
- 2011-2012: Articulum Research Fellow with Prof. Dr. Steffen Gay, University Hospital Zurich & University of Zurich, Zurich, Switzerland
- 2005-2010: PhD in Biomedicine, Faculty of Medicine & Faculty of Electrical Engineering, University of Ljubljana, Slovenia
- 1997-2005: Doctor of Medicine, Faculty of Medicine, University of Ljubljana, Slovenia
Dr. Janine Lückgen
Postdoctoral Researcher
Short Bio
- 2017 – 2022: PhD researcher at the Research Centre for Experimental Orthopaedics, Heidelberg University Hospital, Germany
- 2013 – 2016: Master of Science with Distinction in Molecular and Applied Biotechnology at RWTH Aachen University, Germany
- 2010 – 2013: Bachelor of Science in Biotechnology at RWTH Aachen University, Germany
Tamara Pfanner
PhD Student
Short Bio
- 2022 – present: PhD at the Ludwig-Maximilians-Universität München
- 2019 – 2020: Master of Science with Distinction in Biomedical Science from
Edinburgh Napier University - 2018 – 2019: Biology Studies at the University of Cologne
- 2015 – 2018: Bachelor’s degree from the German Sport University of Cologne
Team PTA Alumni
At BioMed X we care for the people who work with us. Staying in touch with those who left but mainly contributed to BioMed X’s success is key. That’s why they have their designated place on our website. So let’s keep connected!
Dr. Swathi Lingam
Scientific Communication & Editorial Associate
Short Bio
2021-2024: Postdoctoral researcher developing an in vitro model of the human synovium to study immune resolution in rheumatoid arthritis in Team PTA at BioMed X Institute.
2019-2021: Research Fellow in studying retinal ageing and developing novel cell therapy systems to treat age related retinal degeneration at the National University of Singapore and the Agency for Science, Technology and Research (A*STAR), Singapore.
2017- 2019: Postdoctoral scientist studying the function of the ABC transporter ABCC5 in diabetes at the University of Oxford, UK.
2014- 2017: PhD in biochemistry at the University of Manchester, UK.