The EAC research team is exploring the role of epigenetic regulation in the development and progression of chronic obstructive pulmonary disease (COPD). COPD is caused by the persistent inhalation of toxic gases (in particular, cigarette smoke) that lead to chronic inflammation and irreversible remodeling of the lung tissues. COPD is currently one of the leading causes of death worldwide (www.who.int/respiratory/copd/en/); however, there are no curative strategies for this disease at present. Our group employs high-throughput epigenomic assays, such as whole-genome bisulfite sequencing (WGBS), ChIP-seq, and RNA-seq in combination with cutting-edge epigenetic and molecular biology tools to advance the biological understanding of the disease, identify epigenetic biomarkers for diagnosis, and devise novel therapeutic strategies.
Publications
- Jurkowska RZ, Jurkowski TP (2019):
Establishment, erasure and synthetic reprogramming of DNA methylation in mammalian cells
In: The DNA, RNA, and histone methylomes (Springer)
- Llamazares Prada M, Espinet E, Mijosek V, Schwartz U, Waszak SM, Lutsik P, Tamas R, Richter M, Behrendt A, Pohl S, Benz N, Muley T, Warth A, Heussel CP, Winter H, Herth F, Mertens T, Karmouty-Quintana H, Koch I, Benes V, Korbel JO, Trumpp A, Wyatt D, Stahl H, Plass C, Jurkowska RZ (2020):
Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung
JCI Insight 6 (6)
- Schwartz U, Llamazares Prada M, Pohl ST, Richter M, Tamas R, Schuler M, Keller C, Mijosek V, Muley T, Schneider MA, Quast K, Hey J, Heußel CP, Warth A, Winter H, Serçin Ö, Karmouty-Quintana H, Jyothula SS, Patel MK, Herth F, Koch I, Petrosino G, Titimeaua A, Mardin BR, Weichenhan D, Jurkowski TP, Imbusch CD, Brors B, Benes V, Jung B, Wyatt D, Stahl HF, Plass C, Jurkowska RZ (2023): High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD
The EMBO Journal Jun 15;42(12):e111272
