Respiratory

Team EAC

Epigenetics and COPD

The EAC research team is exploring the role of epigenetic regulation in the development and progression of chronic obstructive pulmonary disease (COPD). COPD is caused by the persistent inhalation of toxic gases (in particular, cigarette smoke) that lead to chronic inflammation and irreversible remodeling of the lung tissues. COPD is currently one of the leading causes of death worldwide (www.who.int/respiratory/copd/en/); however, there are no curative strategies for this disease at present. Our group employs high-throughput epigenomic assays, such as whole-genome bisulfite sequencing (WGBS), ChIP-seq, and RNA-seq in combination with cutting-edge epigenetic and molecular biology tools to advance the biological understanding of the disease, identify epigenetic biomarkers for diagnosis, and devise novel therapeutic strategies.

  • Mentors
    • Dr. Heiko Stahl
      Principal Scientist, Exploratory Innovation Unit, Department of Immunology & Respiratory Diseases Research Germany, Boehringer Ingelheim, Germany (Industry mentor)
    • Dr. Renata Jurkowska
      Senior Lecturer, Cardiff University (Academic mentor)
    • Prof. Dr. Christoph Plass
      Division Head, Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (Academic mentor)
  • Publications
    1. Jurkowska RZ, Jurkowski TP (2019):
      Establishment, erasure and synthetic reprogramming of DNA methylation in mammalian cells
      In: The DNA, RNA, and histone methylomes (Springer)
    2. Llamazares Prada M, Espinet E, Mijosek V, Schwartz U, Waszak SM, Lutsik P, Tamas R, Richter M, Behrendt A, Pohl S, Benz N, Muley T, Warth A, Heussel CP, Winter H, Herth F, Mertens T, Karmouty-Quintana H, Koch I, Benes V, Korbel JO, Trumpp A, Wyatt D, Stahl H, Plass C, Jurkowska RZ (2020):
      Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung
      bioRxiv
The research of this team is kindly sponsored by Boehringer Ingelheim.

Our Team Members

Dr. Maria Llamazares

Senior Postdoc

Characterization of primary lung cells to identify COPD-specific epigenetic alterations; epigenetic screens to revert COPD phenotypes

  • Short Bio
    • 2013–2015: Postdoc with Prof. Angel, German Cancer Research Center (DKFZ), Heidelberg, Germany
    • 2010–2012: Postdoc with Prof. Hertl, University Hospital Marburg, Germany
    • 2006–2009: Postdoc with Prof. Eilers, Institute for Molecular and Tumor Biology (IMT, Marburg) and Biozentrum (Würzburg), Germany
    • 2005–2006: Scientist, University of Oviedo, Spain
    • 2001–2005: PhD in Biochemistry and Molecular Biology, University of Oviedo, Spain
    • 2004: Visiting PhD student, University of British Columbia, Vancouver, Canada
    • 2000: Master of Science, Biochemistry and Molecular Biology, University of Oviedo, Spain
  • Contact
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