Oncology

Team RSC: RNA Splicing in Cancer

Emerging data indicate that alterations in RNA splicing play a critical role in the pathogenesis of several molecular subtypes of cancer. Such alterations can lead to constitutive activity of oncogenes, reduced expression of tumor suppressors, or drug resistance. The team is seeking to identify novel approaches to exploit tumor-specific RNA splicing alterations for targeted cancer therapy.

Mentors

  • Dr. Christina Esdar
    Associate Director TIP Oncology at Merck, Darmstadt, Germany (Industry mentor)
  • Prof. Dr. Andreas Kulozik
    Head of the Department of Pediatric Oncology, Hematology, Immunology and Pulmonology at Children’s Hospital, University of Heidelberg, Germany (Academic mentor)
The research of this team is kindly sponsored by Merck.
The research of this team is kindly sponsored by Merck.

Our Team Members

Dr. Jan Mauer

Group Leader

Previous work
  • 2015-2017: Postdoc in RNA biology and epitranscriptomics with Prof. Samie R. Jaffrey at the Department of Pharmacology, Weill Cornell Medicine of Cornell University, New York, USA
  • 2009-2014: Postdoc in mouse models of metabolic and inflammatory diseases with Prof. Jens C. Brüning, at the Institute for Genetics, University of Cologne, Germany and at the Max Planck Institute for Metabolism Research in Cologne, Germany
  • 2004-2009: PhD in Genetics with Prof. Jens C. Brüning at the Institute for Genetics, University of Cologne, Germany

Dr. Alexandra Duarte

Postdoctoral Researcher

Previous work
  • 2013-2018: Research assistant with Dr. Sven Rottenberg and Prof. Jos Jonkers at the Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands
  • 2012-2013: Postdoc with Dr. Rudiger Woscholski at the Department of Chemistry, Imperial College London, UK
  • 2008-2012: PhD with Dr. David Mann at the Department of Life Sciences, Imperial College London, UK

Dr. Lina Marcela Paez

Postdoctoral Researcher

Previous work
  • 2015-2018: Postdoc with Dr. Nuno Morais at the Laboratory of Disease Transcriptomics, Instituto de Medicina Molecular, Lisbon, Portugal
  • 2014-2015: Postdoc with Dr. Raquel Oliveira at the Laboratory of Chromosome Dynamics, Instituto Gulbenkian de Ciencia, Portugal
  • 2010-2014: PhD with Dr. Katsuhiko Shirahige at the Laboratory of Genome Structure and Function, Tokyo Tech/University of Tokyo, Japan