Neuroscience

Team BMP

Brain Microcircuits in Psychiatric Diseases

Psychiatric diseases remain one of the most urgent problems of a modern society. The main reason is insufficient understanding of the biological mechanisms of underlying neural circuit dysfunctions. Specifically, most current therapies are designed to act on neuronal compartments, largely ignoring non-neuronal cells involved in the regulation of critical brain functions.

The main aim of the BMP group is to uncover the contribution of glial cells to brain dysfunctions relevant for human psychiatric diseases. Our strategy is to provide systematic insight into the complex neuro-glia interactions and to identify critical molecular components altered in pathological conditions. To this end, we combine state-of-the-art genetic approaches with advanced methods of visualization of biological processes in cell cultures and in model animals.

  • Mentors
    • Prof. Dr. Bastian Hengerer
      Director CNS Diseases Research at Boehringer Ingelheim (Industry mentor)
    • Prof. Dr. Thomas Kuner
      Head of Department Functional Neuroanatomy, Institute for Anatomy and Cell Biology at the University of Heidelberg (Academic mentor)
  • Publications

    1. Magdalena Tertil, Urszula Skupio, Justyna Barut, Valentyna Dubovyk, Agnieszka Wawrzczak-Bargiela, Zbigniew Soltys, Slawomir Golda, Lucja Kudla, Lucja Wiktorowska, Klaudia Szklarczyk, Michal Korostynski, Ryszard Przewlocki & Michal Slezak (2018):
      Glucocorticoid receptor signaling in astrocytes is required for aversive memory formation
      Translational Psychiatry volume 8, Article number: 255 (2018)

The research of this team is kindly sponsored by Boehringer Ingelheim.

Our Team Members

Dr. Michał Ślęzak

Group Leader

  • Short Bio
    • 2012–2016: Postdoc with Prof. Matthew Holt, VIB Center for the Biology of Disease, KU Leuven, Belgium
    • 2007–2012: Postdoc with Prof. Ryszard Przewłocki, Institute of Pharmacology PAS, Cracow, Poland
    • 2002–2007: PhD with Prof. Frank Pfrieger, Institute of Cellular and Integrative Neuroscience (INCI), Louis Pasteur University, Strasbourg, France
    • 2013–2015: Marie Skłodowska-Curie Intra-European Fellowship
    • 2012: Young Investigator Award from Polish Ministry of Science and Higher Education
  • Contact

Dr. Valentyna Dubovyk

Postdoctoral Researcher

  • Short Bio
    • 2011-2016: PhD with Prof. Denise Manahan-Vaughan, International Graduate School of Neuroscience, Ruhr-University Bochum, Germany
    • 2009-2011: Master of Science in Biophysics, Kyiv National University of Taras Shevchenko, Ukraine
    • 2005-2009: Bachelor of Science in Biology, Kyiv National University of Taras Shevchenko, Ukraine
  • Contact

Luanna Dixson

Bioinformatician

  • Short Bio
    • 2014–2017: MSc Molecular Biosciences (major Neuroscience), Universität Heidelberg
    • 2010-2017: Research Associate, Central Institute for Mental Health, Mannheim, Germany
    • 2009–2010: Imaging Assistant Scientist, GlaxoSmithKline Clinical Imaging Center, London, UK
    • 2004-2007: BSc Biological Sciences (major Human Genetics), University of Liverpool, UK
  • Contact

Laura Bergauer

Research Assistant

  • Short Bio
    • 2016–2018: Master of Science in Biotechnology at Mannheim University of Applied Sciences, Germany
    • 2015: Internship at ZI Mannheim, Department Molecular Biology, Germany
    • 2012–2016: Bachelor of Science in Biotechnology at Mannheim University of Applied Sciences, Germany
  • Contact

Sedef Dalbeyler

PhD Student

  • Short Bio
    • 2015–2016: Research assistant in Laboratory of Glia Biology, Department of Human Genetics at KU Leuven, VIB, Belgium
    • 2013–2015: Master of Science in Biomedical Sciences, KU Leuven, Belgium
    • 2008–2013: Bachelor of Science in Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey
  • Contact

Shringarika Singh

Research Assistant

  • Short Bio
    • 2017–2018: Master Thesis Project ‘Genome editing of induced pluripotent stem cells (iPSCs) derived from Huntington´s disease patients Using CRISPR/Cas9’ at Max-Delbrück-Centrum for Molecular Medicine (MDC), Berlin, Germany
    • 2015–2018: Master of Science in Biomedical Engineering at University Furtwangen, Villingen-Schwenningen, Germany
    • 2014: Bachelor Thesis Project ‘Immuno-Histological Analysis of Kidney in Diabetic’ at Sanjay Gandhi Post Graduate Institute of Medical Sciences, Department of Molecular Medicine, India
    • 2010–2014: Bachelor of Technology in Biotechnology at Amity University, India
  • Contact

Theo Luciani

Intern

  • Short Bio
    • Since 2017: Engineer school in Chemistry and Biotechnology at CPE Lyon, France
    • 2019: internship in 3D micro-printing and skin cell culture within 3D Fabric of Advanced Biology (3d.FAB), LabSkin Creations and Newtone Technologies, Lyon, France
    • 2017: Bachelor of Sciences in Chemistry and Process Engineering at CPE Lyon, France
  • Contact

Laura Schmidt

Intern

  • Short Bio
    • Since 2019: Master of Science in Biochemistry, Ruprecht-Karls-University, Heidelberg, Germany
    • 2019: Bachelor’s thesis project „Crosstalk between polyadenylation and mRNA export machineries“, Hudson Institute of Medical Research, Melbourne, Australia & Monash University, Melbourne, Australia
    • 2017-2019: Student assistant at Sträßer laboratory, Justus Liebig University, Gießen, Germany
    • 2017-2019: Bachelor of Science in Biology, Justus Liebig University, Gießen, Germany
  • Contact
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