Immunology

Team IEB

Intestinal Epithelial Barrier in Autoimmune Diseases

The intestinal epithelium provides an essential selective barrier that permits passage of water, ions and nutrients, while limiting contact with harmful environmental toxins and preventing microbial contamination of interstitial tissues. Loss of intestinal barrier function is correlated with several autoimmune diseases. The main objective of the IEB group is to understand the molecular mechanisms of the interactions between intestinal epithelial barrier and immune cells in autoimmune diseases, in particular the interactions between dendritic cells and intestinal enterocytes. To this end, studies will involve use of conventional and high-throughput metagenomics, generation of intestinal organoids from murine and human subjects, isolation of immune cells and establishing a 3 dimensional In-vitro co-culture model to observe the intestinal epithelial barrier-immune cells interactions. Our final goal is to identify novel biomarkers and develop new therapeutic targets for intestinal barrier loss and autoimmune diseases that will improve patient outcomes.

 Mentors
  • Dr. Daigen Xu
    Associate Director, TIP Immunology, EMD Serono (Industry mentor)
  • Dr. Philipp Haselmayer
    Associate Director TIP-Immunology, Merck KGaA, Darmstadt, Germany (Industry mentor)
  • Prof. Dr. Christoph Becker
    Head of Department Mucosal Immune Regulation and Intestinal Cell Biology, University Hospital Erlangen, Germany (Academic mentor)
The research of this team is kindly sponsored by Merck

Our Team Members

Dr. Martin Resnik Docampo

Group Leader

 Short Bio
  • 2017-2019: Assistant Project Scientist, Molecular Cell and Developmental Biology Department, University of California, Los Angeles USA
  • 2013-2017: Postdoctoral Researcher, Advisor: Prof. Dr. Leanne Jones, Molecular Cell and Developmental Biology Department, University of California, Los Angeles, USA
  • 2012-2013: Research Associate in Prof. Dr. Leanne Jones laboratory
  • 2004-2011: PhD in Biochemistry and Molecular Biology with Dr. Jose Felix de Celis, Universidad Autonoma de Madrid, Center for Molecular Biology “Severo Ochoa”, Spain
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Dr. Ibrahim Murathan Sektioglu

Postdoctoral Researcher

 Short Bio
  • 2019-2021 : Scientist at Phenex Pharmaceuticals and WMT, Heidelberg, Germany
  • 2018-2019 : Postdoctoral Researcher at German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 2011-2015 : PhD researcher at German Cancer Research Center (DKFZ), Heidelberg, Germany
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Dr. Inga Hensel

Postdoctoral Researcher

 Short Bio
  • 2016 – 2020: PhD researcher in the Department of Gastroenterology, Medical School Hannover, Germany
  • 2014 – 2016: Master of Science in Molecular Medicine, Friedrich-Schiller-University, Jena, Germany + University in Tromso, Norway
  • 2011 – 2014: Bachelor of Science in Biochemistry, Ruhr-University Bochum, Germany
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Szabolcs Éliás

Bioinformatician

 Short Bio
  • 2018 – 2020: Postdoc in Machine Learning and Bioinformatics, Roche, Pharma Research and Early Development, Germany
  • 2011 – 2018: PhD in Bioinformatics and T Cell Immunology, Karolinska Institute, Center for Molecular Medicine, Unit of Computational Medicine, Sweden
  • 2010 – 2011: Master of Science in Human Molecular Genetics, Imperial College London, UK
  • 2006 – 2010: Bachelor of Science in Biochemical Engineering, Budapest University of Technology and Economics, Hungary
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Michelle Vormehr

PhD Student

 Short Bio
  • 2017-2019: Master of Science in Biology, University of Mainz, Germany
  • 2018: ERASMUS studies in Molecular and Cellular Biology, University of Glasgow, Scotland
  • 2014-2017: Bachelor of Science in Biology, University of Mainz, Germany
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Bilgenaz Özkan

Research Assistant

 Short Bio
  • 2019-2020: Research Assistant, Center for Molecular Biology (ZMBH) of Heidelberg University, Germany
  • 2017-2019: Master of Science in Life Sciences, Gwangju Institute of Science and Technology, South Korea
  • 2011-2016: Bachelor of Science in Molecular Biology and Genetics, Istanbul Technical University, Turkey
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Team IEB Alumni

At BioMed X we care for the people who work with us. Staying in touch with those who left but mainly contributed to BioMed X’s success is key. That’s why they have their designated place on our website. So let’s keep connected!

Dr. Roberta Benedetto

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Dr. Shaghayegh Derakhshani

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Dr. Sarah Devriese

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Gizem Chelik

Master's Student

 Short Bio
  • 2019-2021: Internships at BiomedX, ZMBH, DKFZ and NCT, Heidelberg, Germany
  • 2018-2021: Master in Molecular Biosciences (Molecular and Cellular Biology), Heidelberg University, Germany
  • 2015-2018: Bachelor in Biological Sciences, Heidelberg University, Germany
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África Temporal Plo

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