Immunology

Team IAA: Rapid Identification of Auto-Antigens in Autoimmune Diseases

The team is seeking new platform technologies or concepts which lead to identification of antigens recognized by T-cells involved in autoimmune responses. The objective of the group is to deconvolute the autoimmune T-cell receptor (TCR) repertoire functionally with respect to unknown cognate peptide: HLA complexes. We will use high-throughput screening approaches coupling sequence to specificity in order to identify critical points of attack in the treatment of autoimmune diseases.

Mentors

  • Dr. Nathan Felix
    Principal Scientist, Janssen Immunosciences, Spring House, USA (Industry mentor)
  • Prof. Dr. Christof von Kalle
    Managing Director, National Center for Tumor Diseases, Heidelberg, Germany (Academic mentor)
The research of this team is kindly sponsored by Janssen.

Our Team Members

Dr. John Lindner

Group Leader

Previous work
  • 2014-2018: Post-doc in autoimmune antibody repertoires with Dr. Elisabetta Traggiai at the Novartis Institutes for BioMedical Research, Basel, Switzerland
  • 2008-2013: PhD (molecular immunology) in B-cell transcriptional control with Dr. Peter Nielsen in the Department of Prof. Michael Reth at the Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Dr. Yonatan Herzig

Postdoctoral Researcher

Previous work
  • 2016-2018: Postdoctoral fellow focusing on inflammasome activation in health and disease in the laboratory of Prof. Eicke Latz, The Institute for Innate Immunity, University Hospital of Bonn, Germany
  • 2011-2016: Ph.D in Biology focusing on adaptive immunity and central immune tolerance, in the laboratory of Dr. Jakub Abramson, Weizmann Institute of Science, Rehovot, Israel
  • 2009-2011: M.Sc in Biology focusing on establishing yeast-based high throughput systems to study cellular protein trafficking in the laboratory of Dr. Maya Schuldiner, Weizmann Institute of Science, Rehovot, Israel

Kamaldeep Kaur

PhD Student

Previous work
  • 2015-2018: Master of Science in Biochemistry at University of Zurich
  • 2013-2015: Project Engineer, Wipro Limited, India
  • 2009-2013: Bachelor of Technology in Biotechnology at Amity University, Delhi, India

Veronica Pinamonti

Research Assistant

Previous work
  • 2015-2018: Master of Science in Cellular and Molecular Biotechnology, CIBIO – University of Trento, Italy
  • 2017: Vienna Biocenter Summer School 2017, Vienna Austria
  • 2012-2015: Bachelor of Science in Biomolecular Science and Technology, CIBIO – University of Trento, Italy