“Understanding Cilia-Mediated Autophagy in the Central Nervous System”, Olatz Pampliega, Achucarro Basque Center for Neuroscience, Spain

Speaker: Olatz Pampliega, Achucarro Basque Center for Neuroscience, Spain

Host: Postdocs BioMed X

Abstract

As most cell types in the body, neurons and astrocytes in the CNS possess a primary cilium that responds to extracellular events, such as hormones and neurotrophic factors, which in turn are able to modulate autophagy. The laboratory of Dr. Pampliega studies the mechanisms that govern the interactions between autophagy and the primary cilium in neurons and astrocytes, as well as the interplay between these two cell types.

In this seminar, Dr. Pampliega will present data showing that neuronal cilia mediate the autophagic response in neurons in response to an acute amyloid beta overload. Moreover, using mice lacking neuronal cilia, the Pampliega group have observed that cilia mediated autophagy is differentially modulated in males and females, and that this is an age-dependent event.

More recently, they have become interested in deciphering if, in addition to neuronal cilia, the astrocytic cilium also plays a role in sensing extracellular amyloid beta, and if it exists a coordinated response of these two cell types through their primary cilium.

Overall, the Pampliega group aim to understand the role of the primary cilium in the adult central nervous system, as well as its role in modulating autophagy in pathophysiological conditions.