“Novel Insights into the Roles of Epigenetic Enzymes and Readers in Health and Disease”, Albert Jeltsch, University of Stuttgart, Germany

Speaker: Prof. Dr. Albert Jeltsch, University of Stuttgart, Germany

Host: Dr. Renata Jurkowska, BioMed X

Abstract

Molecular epigenetics comprises DNA and chromatin modifications and the readout of the chromatin marks. I will present unpublished examples of our work studying DNA methyltransferases, Protein lysine methyltransferase and methyl-readers.

In the first part of my talk, I will describe novel methods and results for the analysis of the specificity of DNA methyltransferases, which help to enlighten the pathogenic mechanism of the R882H mutation frequently occurring in AML and the cellular role of DNMT3A and DNMT3B.

In the second part, I will present novel results of the specificity analysis of the human histone methyltransferase SETD2, which reveal interesting conclusion on the biological role and evolution of this enzyme.

Finally, I will describe our bimolecular reconstitution sensor for the locus specific readout of epigenetic states in living cells.

About Albert

Prof. Albert Jeltsch studied Biochemistry in Hannover, where he received his PhD in 1994 working on restriction endonucleases. Afterwards he started his work on DNA methyltransferases and moved to Giessen where he received his Habilitation in 1999. He was appointed as Assistant Professor in Giessen, and as Associated Professor in Biochemistry at Jacobs University Bremen in 2003. Since 2006 he was Full Professor in Biochemistry and 2011 he moved to University Stuttgart, where he is heading the Department of Biochemistry in the Institute of Biochemistry and Technical Biochemistry.

The group of Prof. Jeltsch is leading in the biochemical study and enzymology of DNA methyltransferases. They have long standing expertise in the field of rational and evolutionary protein design of DNA interacting enzymes and in the design of chimeric methylation enzymes for gene regulation in eukaryotic cells. In addition, they work in the field of Molecular Epigenetics where they study the specificity and activity of histone methyltransferases and methyl lysine reading domains and provided seminal discoveries in both fields.

Prof. Jeltsch has >280 publications with >16000 citations and an H-index of 64. He received the Gerhard-Hess award of the DFG in 1999 and the BioFuture Award of the Federal Minister of Research and Education (BMBF) in 2001. He is member in several editorial boards (including Nucl. Acids Res., Scientific Reports, ChemBioChem, Clinical Epigenetics, and Biochimie) and several university committees.