“(Im)precision Genomics”, Massimo Delledonne, University of Verona, Italy

Speaker: Massimo Delledonne, University of Verona, Italy

Host: Postdocs, BioMed X

Abstract

DNA sequencing technologies have evolved (and are still evolving) at a prodigious rate. This has led to global boom in whole genome or exome sequencing, boosting the discovery of sequence variants associated with disease that will eventually be translated into new diagnostic, prognostic, and therapeutic targets for individual patients in the so called “precision medicine”.

However, there are many limitations in the current genomic sequencing approaches that we must understand and, especially, keep into account when performing analyses especially in the clinical settings. Understanding the current limitations of genomic technologies and applying these technologies and their methods to tackle the appropriate question is therefore a fundamental aspect of precision medicine.

So, there are many technologies now available for genomic analyses, but which is the right one for your application? In order to answer to this question, Prof. Delledonne will give an overview of current and emerging genomic technologies focusing on their pros and cons when adopted in a research environment and in a clinical setting.

About Massimo

Massimo Delledonne received his Ph.D. from Università Cattolica del S. C. (Piacenza, Italy) in 1994. During 1995-1998 he visited the Salk Institute for Biological Studies (CA, USA) discovering the function of nitric oxide in plant disease resistance. In 2001, he joined the University of Verona (Verona, Italy) as Associate Professor of Plant Genetics. He embraced next generation sequencing technologies in 2007, when he founded the Center of Functional Genomics, which is dedicated to the development and use of the new tools that the new genomic technologies are offering to microbial, plant, animal and human biologists.

Massimo Delledonne is currently Full Professor of Genetics. He coordinates an extensive program of research characterized by an interdisciplinary approach that connects genetics, molecular biology, bioinformatics and genomics, specializing on the characterization of those parts of the genome that are not shared among all genotypes of a species and that can contribute to the establishment of differences in phenotype. Human genome sequencing and interpretation in a clinical setting, and comparison and benchmarking of current and emerging genomic technologies, are others integral parts of his mission.