“Gene Regulation Mediated by Non-Coding RNAs, RNA Binding Proteins and RNA Modifications”, Gunter Meister, University of Regensburg, Germany

Speaker: Prof. Dr. Gunter Meister, University of Regensburg, Germany

Host: Dr. Jan Mauer, BioMed X

Abstract

Gene expression is not only regulated at the level of transcription, but also at many post-transcriptional steps.
Various classes of non-coding RNAs have been identified that are vital for correct gene expression. This large RNA family includes microRNAs, lncRNAs or circular RNAs, which are generated by alternative splicing and can function as sponges for miRNAs or RNA-binding proteins.

RNAs do not function as sole RNA molecules but are instead incorporated into RNA-protein complexes, in which at least one RNA-binding protein (RBP) contacts the RNA directly. Consequently, RBPs are essential for RNA metabolism and serve as regulatory hubs to coordinate the various RNA-guided processes.
Mis-regulation of such processes is often associated with disease, a phenomenon that is generally underestimated.
Prof. Meister’s team has recently described how RBPs regulate miRNA expression on a co- or post-transcriptional level. In addition, they have started to investigate RNA modification pathways and their cross talks with other cellular RNA regulatory networks in human cells.

Prof. Meister will present the recent progress on RBP functions including readers and writers of RNA base modifications. He will also present his team’s efforts to generate robust and reliable tools for studying RNA modifications.

About Prof. Meister

2009- present: Full professor (biochemistry), University of Regensburg

2005- 2010: Independent Group Leader at the Max-Planck-Institute of Biochemistry in Martinsried; Laboratory of RNA Biology

2003- 2004: Postdoctoral Fellow, Rockefeller University, New York, NY, USA, Laboratory of T. Tuschl, Ph.D.

1999‐ 2002: Dr. rer. nat. Biochemistry, LMU Munich and Max-Planck-Institute for Biochemistry, Germany