“How Memories are Stored and Recalled – Insights from Alzheimer’s Disease Models”, Dr. Martin Fuhrmann, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany

Speaker: Martin Fuhrmann, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany

Host: Dagmar Ehrnhöfer, BioMed X

Abstract: We are interested to understand the neuronal networks involved in learning and memory. One of the primary brain regions involved in learning and memory is the hippocampus. The hippocampus is severely affected in patients with Alzheimer’s disease (AD) by the common hallmarks Ab- and tau-pathology. We are using mouse models to recapitulate aspects of AD and to better understand how learning and memory processes are disturbed under disease conditions to draw conclusions about the normal healthy status. We combine in vivo imaging approaches with electrophysiology, optogentics, chemogenetics, behaviour and immunohistochemistry to understand mechanisms underlying learning and memory. I will present recent unpublished findings from my laboratory. The first part will be about memory traces and their disturbances under AD-like conditions. The second part will deal with aberrant oscillations in the hippocampus and the role of inhibitory interneurons as a potential therapeutic target for the treatment of AD.

About Martin

  • since 2010 Head of Neuroimmunology and Imaging, DZNE Bonn
  • 2006 – 2010 Postdoc Center for Neuropathology and Prion Research, LMU-Munich
  • 2002 – 2006 PhD Center for Neuropathology and Prion Research, LMU-Munich