“Alpaca Nanobodies as Tools to Study the Cell Biology of the Immune System”, Dr. Florian I. Schmidt, Institute of Innate Immunity, University of Bonn, Germany
Speaker: Dr. Florian I. Schmidt, Institute of Innate Immunity, University of Bonn, Germany
Host: Dr. Lee Kim Swee, BioMed X
Florian Schmidt and his team seek to uncover the molecular mechanisms that govern innate immune responses in the cell. They use custom-made alpaca single domain antibodies (nanobodies or VHHs) to perturb, visualize and ultimately understand immunological signaling cascades in the responding cell types at endogenous protein levels. They investigate the activation mechanism of orphan inflammasome sensors and try to reveal how virus infection triggers the assembly of inflammasome complexes in different cell types. To delineate common strategies, they compare the responses to DNA and RNA viruses including herpesviruses (HSV-1), orthomyxoviruses (influenza A virus), poxviruses (vaccinia virus), and rhabdoviruses (vesicular stomatitis virus).
- since 2017: Emmy Noether Research Group Leader at Institute of Innate Immunity, University of Bonn, Germany
- 2016- 2017: Postdoctoral Researcher at Boston Children’s Hospital, USA
- 2013-2016: Postdoctoral Fellow at Whitehead Institute, USA